Integrated Traditional Chinese and Western Medicine Therapeutic Strategies for Diabetic Kidney Disease under the Guidance of "Diseased Collateral" Theory
10.13288/j.11-2166/r.2026.13.007
- VernacularTitle:病络理论指导下的糖尿病肾脏病中西医结合辨治思路
- Author:
Yuzi CAI
1
;
Huijuan ZHENG
1
;
Weijun HUANG
1
;
Yue JI
1
;
Yizhen HAN
1
;
Weiwei SUN
1
;
Yuning LIU
1
;
Yaoxian WANG
2
;
Weijing LIU
1
Author Information
1. Dongzhimen Hospital，Beijing University of Chinese Medicine，Beijing，100700
2. Beijing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
diabetes kidney disease;
diseased collateral;
integrated traditional Chinese and western medicine therapy
- From:
Journal of Traditional Chinese Medicine
2026;67(13):1390-1396
- CountryChina
- Language:Chinese
-
Abstract:
Based on the theory of diseased collaterals and the progression pattern of diabetic kidney disease （DKD）， this paper proposes a staged treatment system based on the "three states of kidney collaterals" including collateral distention， collateral bi （痹） and collateral accumulation. In the collateral distention stage， the primary pathogenesis is heat damaging the kidney collaterals and collateral vessel dilation， corresponding to the early state of DKD characterized by hyperfiltration and microalbuminuria； the clearing method is suggested， and Shenling Jiangtang Formula （参苓降糖方） can be used to promote the remission of proteinuria by ameliorating insulin resistance and regulating intestinal microecology. In the collateral bi stage， the core pathogenesis lies in the binding of phlegm and stasis， and the formation of concretions and conglomerations in the kidney collaterals， corresponding to massive proteinuria and the decline of renal function， for which the unblocking method should be taken， using Jinchan Yishen Tongluo Formula （金蝉益肾通络方） and Qingre Xiaozheng Formula （清热消癥方） to alleviate renal pathological damage by regulating the autophagy-lysosome pathway and repairing mitochondrial energy metabolism. The collateral accumulation stage is characterized by the internal retention of turbid toxins and accumulations of concretions in the kidney collaterals， corresponding to renal fibrosis and end-stage renal disease （ESRD）； the dispersion method is suggested， and Yiqi Tongluo Xiezhuo Formula （益气通络泄浊方） and Shenyan Fangshuai Fluid （肾炎防衰液） can be used to inhibit extracellular matrix accumulation and delay the progressive loss of renal function. Collateral deficiency runs through the entire course of the disease and is closely related to cellular senescence and the imbalance of the ubiquitin-proteasome/autophagy system. The concept of the "three states of kidney collaterals" integrates the evolution of traditional Chinese medicine pathogenesis with modern pathological staging， forming a whole-course intervention system of "staging-syndrome differentiation-target-formula"， thereby providing novel insights for prevention and treatment of DKD using integrated traditional Chinese and western medicine.
