Pathogenesis Evolution and Treatment Strategies of Inflammation-Cancer Transformation in Helicobacter Pylori-Associated Gastritis：Based on the Theory "Latent Wind in Stomach Collaterals"
10.13288/j.11-2166/r.2026.13.006
- VernacularTitle:从“胃络伏风”探讨幽门螺杆菌相关性胃炎“炎-癌”转化的病机演变规律及治疗策略
- Author:
Chuanyang LIU
1
;
Lin CHENG
1
;
Xinqiao CHU
2
;
Shuxuan CHEN
2
;
Zhihua TIAN
2
;
Shaoli WANG
2
;
Zhen LIU
2
Author Information
1. Beijing University of Chinese Medicine，Beijing，100029
2. Guang'anmen Hospital，China Academy of Chinese Medical Sciences
- Publication Type:Journal Article
- Keywords:
helicobacter pylori-associated gastritis;
inflammation-cancer transformation;
latent wind;
stomach colla-terals;
wind toxin
- From:
Journal of Traditional Chinese Medicine
2026;67(13):1383-1389
- CountryChina
- Language:Chinese
-
Abstract:
It is considered that "latent wind in stomach collaterals" is the core pathogenesis underlying the inflammation-caner transformation of helicobacter pylori-associated gastritis （HpAG）. The concept of "latent wind in stomach collaterals" integrates stomach wind theory， latent pathogen theory， and collateral disease theory， referring to wind pathogen deeply hidden in the stomach collaterals， characterized by both external and internal wind pathogen as well as latent pathogen that remain concealed and may be triggered under certain conditions. Accordingly， the Correa cascade is reclassified into four stages including the prodromal stage， progressive stage， transitional stage and carcinogenic stage. In the prodromal stage， the fundamental pathogenesis is described as "wind toxin invading externally with collateral deficiency and stirring of wind". In the progressive stage， wind is accompanied by qi constraint， fire pathogen， and dryness pathogen， manifesting as "wind pathogen complicated by constraint" "wind-fire agitation" and "wind-dryness interaction". In the transitional stage， "wind transforming into phlegm-drool and stomach collaterals being obstructed by stasis" is identified as a critical window for disease reversal. In the carcinogenesis stage， "wind-qi hyperactivity leading to pathological transformation， and collateral damage resulting in abdominal masses" drives tumor progression and metastasis. This paper proposes the treatment principle of "wind-dispelling throughout the entire process and stage-based treatment"， according to the pathological evolution of "collateral deficiency-collateral stagnation-collateral accumulation". In the prodromal stage， it is suggested to dispel wind and resolve toxin， fortify spleen and tonify collaterals； in the progressive and transitional stage， the method of dispelling wind pathogen， clearing phlegm and eliminating stasis should be used； in the carcinogenesis stage， it is suggested to expel wind and remove pathogens from collaterals， disperse concretions and eliminate tumors.
