Research progress on the regulation of macrophage-bone marrow mesenchymal stem cell interactions by yin-nourishing and kidney-tonifying Chinese herbal medicines to promote tendon-bone healing
- VernacularTitle:滋阴补肾中药通过巨噬细胞和骨髓间充质干细胞的交互作用促进腱骨愈合的研究进展
- Author:
Peng ZHANG
1
;
Guorui CAO
2
;
Honglüe TAN
2
;
Renkun ZHAO
3
;
Mingyang ZHANG
4
;
Dongdong XIE
5
;
Weihao YU
6
Author Information
1. Graduate School，Hunan University of Chinese Medicine，Changsha 410208，China;Dept. of Knee Surgery，Luoyang Orthopedic Hospital of Henan Province（Orthopedic Hospital of Henan Province），Henan Luoyang 471002，China
2. Dept. of Knee Surgery，Luoyang Orthopedic Hospital of Henan Province（Orthopedic Hospital of Henan Province），Henan Luoyang 471002，China
3. Second Dept. of Spine，Wangjing Hospital of China，Academy of Chinese Medical Sciences，Beijing 100102，China
4. Dept. of Knee Surgery，Luoyang Orthopedic Hospital of Henan Province（Orthopedic Hospital of Henan Province），Henan Luoyang 471002，China;School of Orthopedics and Traumatology，Henan University of Chinese Medicine，Zhengzhou 450046，China
5. Dept. of Knee Surgery，Luoyang Orthopedic Hospital of Henan Province（Orthopedic Hospital of Henan Province），Henan Luoyang 471002，China;School of Nursing，Fujian University of Traditional Chinese Medicine，Fuzhou 350122，China
6. Graduate School，Hunan University of Chinese Medicine，Changsha 410208，China
- Publication Type:Journal Article
- Keywords:
tendon-bone healing;
yin-nourishing and kidney-tonifying;
macrophages;
bone marrow mesenchymal stem cells;
crosstalk;
signaling pathways
- From:
China Pharmacy
2026;37(12):1654-1660
- CountryChina
- Language:Chinese
-
Abstract:
The crosstalk between macrophages and bone marrow mesen chymal stem cells （BMSCs） plays a vital role in regulating tendon-bone healing. Based on the traditional Chinese medicine （TCM） theory that the kidney governs the bones and generates marrow， yin-nourishing and kidney-tonifying Chinese medicines can promote the osteogenic differentiation of BMSCs and the M1-to-M2 polarization of macrophages， thereby facilitating tendon-bone healing. A variety of related medicinal monomers （such as diosgenin and oleanolic acid）， extracts and effective fractions （such as artificial tiger bone powder and total flavonoids of Drynaria fortunei ）， as well as compound prescriptions （such as Liuwei dihuang pill， Xujin jiegu decoction and Duhuo jisheng decoction）， can modulate the crosstalk between macrophages and BMSCs by regulating the Wnt/β-catenin， nuclear factor kappa-B， phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin and transforming growth factor-β/Smad signaling pathways. They further exert anti-inflammatory， antioxidant and osteogenic effects to effectively accelerate tendon-bone healing. However， current evidence was limited to animal experiments exhibiting such as limitations insufficent alignment between animal models and clinical injury types， research focusing mostly on single signaling pathways， and unclear core active ingredients. Future studies shall optimize animal models and carry out large-sample randomized controlled trials， clarify the interactive networks of multiple signaling pathways， and isolate the core active substances of yin-nourishing and kidney-tonifying Chinese medicines， so as to advance the precise application of traditional Chinese medicines.
