Research progress on traditional Chinese medicine interventions in colorectal cancer metastasis based on tumor microenvironment
- VernacularTitle:基于肿瘤微环境探讨中药干预结直肠癌转移的研究进展
- Author:
Yu WANG
1
;
Jingyi ZHANG
1
;
Siyu WU
1
;
Bowen SUI
2
Author Information
1. The First Clinical Medical College，Heilongjiang University of Chinese Medicine，Harbin 150040，China
2. Dept. of Oncology Ⅰ，the First Affiliated Hospital，Heilongjiang University of Chinese Medicine，Harbin 150040，China
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
tumor metastasis;
tumor microenvironment;
traditional Chinese medicine active ingredients;
traditional Chinese medicine formulas
- From:
China Pharmacy
2026;37(12):1648-1653
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer has an insidious onset， and some patients have already developed local invasion or metastasis at the time of diagnosis， which affects treatment strategy selection and survival prognosis. The tumor microenvironment is not only the basic condition for tumor cell survival but also the core regulatory factor driving their local invasion and distant metastasis. This article reviewed the mechanisms by which traditional Chinese medicine regulates the tumor microenvironment to inhibit colorectal cancer metastasis. It was found that traditional Chinese medicine active ingredients such as astragalus polysaccharides， leonurine， kaempferol， etc.， as well as traditional Chinese medicine formulas such as Jianpi jiedu formula， can inhibit colorectal cancer metastasis by regulating key links of the tumor microenvironment， including immunosuppression， inflammatory response， intestinal microecological disorder， abnormal angiogenesis， and extracellular matrix homeostasis imbalance. However， current related research was still mainly based on cell and animal experiments， with limited clinical evidence-based data， and mechanistic studies mostly focued on single signaling pathways. Future research should integrate multi-omics technologies and systems biology methods to systematically elucidate the key targets and action networks through which traditional Chinese medicine regulates the colorectal cancer tumor microenvironment to combat metastasis.
