Study on the stability and compatibility of butorphanol，nicardipine，urapidil and tirofiban administered via micro-infusion pump
- VernacularTitle:布托啡诺、尼卡地平、乌拉地尔和替罗非班经微量注射泵配伍给药的稳定性与相容性研究
- Author:
Xiaoyu ZHAO
1
;
Shuyi DUAN
2
;
Xuna AN
3
;
Liting ZHANG
2
;
Liju FAN
1
;
Jing AN
4
;
Zhanjun DONG
1
Author Information
1. School of Pharmacy，Hebei Medical University，Shijiazhuang 050017，China;Dept.of Pharmacy，Hebei General Hospital，Shijiazhuang 050051，China
2. School of Pharmacy，Hebei Medical University，Shijiazhuang 050017，China
3. Dept. of Neurology V，Hebei General Hospital，Shijiazhuang 050051，China
4. School of Pharmacy，Hebei Medical University，Shijiazhuang 050017，China;Dept.of Pharmacy，Hebei General Hospital，Shijiazhuang 050051，China;Hebei Provincial Key Laboratory of Clinical Pharmacy，Shijiazhuang 050051，China
- Publication Type:Journal Article
- Keywords:
butorphanol;
nicardipine;
urapidil;
tirofiban;
micro-infusion pump;
combined infusion;
stability;
compatibility
- From:
China Pharmacy
2026;37(12):1626-1630
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the stability and compatibility of butorphanol， nicardipine， urapidil， and tirofiban. METHODS A micro-infusion pump was used to simulate the infusion process. Samples were collected in real time from the needle tip at 0， 2， 4， 6， and 8 h after mixing of the four drugs. The appearance， pH， and number of insoluble particles were examined. The contents of butorphanol， nicardipine， urapidil， and tirofiban were determined using the ultra-high-performance liquid chromatography method. RESULTS Within 8 hours， all mixed solutions remained clear and transparent， with no visible turbidity， precipitation， color change， or gas generation. The pH fluctuation ranged from 0.02 to 0.09， both within 0.1 pH units. The number of insoluble particles ≥10 μm in size in each compatibility solution was ≤9， and the number of insoluble particles ≥25 μm was ≤2， meeting the requirements of the 2025 edition of the Chinese Pharmacopoeia （Volume Ⅳ）. The relative percentage contents of butorphanol， nicardipine， urapidil， and tirofiban at 8 hours after compatibility mixing ranged from 92.38% to 113.40%. CONCLUSIONS Within 8 hours under simulated clinical micro-infusion pump infusion conditions， the stability and compatibility of the mixed solution containing butorphanol， nicardipine， urapidil， and tirofiban were satisfactory.
