Guidelines for establishing animal models of rheumatoid arthritis with cold dampness obstruction pattern and damp heat obstruction pattern (2024 Version)
10.1097/st9.0000000000000125
- Author:
Na LIN
1
;
Yanqiong ZHANG
1
;
Changhong XIAO
2
;
Shenghao TU
3
;
Jianning SUN
4
;
Shijun XU
5
;
Xia MAO
1
Author Information
1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China
2. Southern Medical University Hospital of Integrative Chinese and Western Medicine, Guangzhou, China
3. Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
4. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China
5. School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
- Collective Name:Representative working group
- Publication Type:Journal Article
- Keywords:
Animal model;
Cold dampness obstruction pattern;
Damp heat obstruction pattern;
Guidelines;
Rheumatoid arthritis
- From:
Science of Traditional Chinese Medicine
2026;4(2):174-180
- CountryChina
- Language:English
-
Abstract:
Rheumatoid arthritis belongs to arthralgia in the theory of traditional Chinese medicine, with cold dampness obstruction pattern (CDO) and damp heat obstruction pattern (DHO) as the main pattern types. Fine therapeutic effects have been obtained in clinical practice following the differentiation of CDO and DHO. However, suitable animal models are not available currently. For adapting to the clinical diagnosis, as well as carrying out basic research of integrated Chinese and Western medicine and preclinical study on new Chinese medicine in a better way, the “Guidelines for Establishing Animal Models of Rheumatoid Arthritis with Cold Dampness Obstruction Pattern and Damp Heat Obstruction Pattern” (referred to as “Guidelines”) were compiled by our research group in cooperation with renowned experts in clinical, pharmaceutical, zoological, and methodological research fields. According to the theory of disease and syndrome integration, experts standardized the establishment methods for animal models of rheumatoid arthritis with CDO and DHO. The Guidelines were compiled via the nominal group method according to the principle of evidence coming in main place, consensus as the auxiliary, and experience as the references. Contents such as animal species, arthritis induction methods, external stimulation conditions, and assessment indicators were specified in the Guidelines based on the comprehensive evaluation of pathogenesis homology, behavioral phenotypic consistency, and drug therapy predictability between animal models and human diseases. The Guidelines will be applicable to the research on syndromes in rheumatoid arthritis, elucidation of acting mechanism, and development of new medicine, and provide reference for standardizing other types of animal models with the integration of disease and syndrome, to promote the modernization of Chinese medicine research.
