Membranous nephropathy with light chain-restricted deposition secondary to small lymphocytic lymphoma: a case report
10.12025/j.issn.1008-6358.2026.20251614
- VernacularTitle:继发于小淋巴细胞淋巴瘤的伴轻链限制性沉积膜性肾病1例报告
- Author:
Youliang WANG
1
;
Yizhuo ZHANG
1
;
Duqun CHEN
1
;
Dandan QIU
1
;
Shaoshan LIANG
1
;
Zhen CHENG
1
;
Zhaohong CHEN
1
Author Information
1. Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, National Clinical Research Center for Kidney Diseases, Nanjing 210016, Jiangsu, China.
- Publication Type:Clinicalcaseanalysis
- Keywords:
small lymphocytic lymphoma;
light chain-restricted deposition;
membranous nephropathy;
adult
- From:
Chinese Journal of Clinical Medicine
2026;33(3):555-560
- CountryChina
- Language:Chinese
-
Abstract:
The patient was a 56-year-old man who presented with abnormal urinalysis findings of over one month’s duration. Serological tests revealed an elevated serum free light chain κ/λ ratio, and immunofixation electrophoresis detected an IgG-κ monoclonal band. Renal biopsy demonstrated membranous nephropathy, with electron-dense deposits observed in the subepithelial space and mesangium on electron microscopy. Immunofluorescence confirmed glomerular deposits of IgG1/IgG3-κ. Based on clinical manifestation, bone marrow flow cytology, and lymph node pathology, the patient was diagnosed with small lymphocytic lymphoma (SLL), and membranous nephropathy with light chain-restricted deposition (IgG1/IgG3-κ) secondary to SLL. After receiving obinutuzumab treatment, the patient’s proteinuria partially remitted, the lymph nodes significantly shrank, and clinical remission was achieved.
