Mechanism and clinical application of traditional Chinese medicine in treatment of cholestatic liver injury by regulating oxidative stress

Yinpei TANG; Linjing SHE; Zhengwang ZHU; Bing WANG; Pingsheng ZHU

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Mechanism and clinical application of traditional Chinese medicine in treatment of cholestatic liver injury by regulating oxidative stress

VernacularTitle:中药调控氧化应激治疗胆汁淤积性肝损伤的机制及临床应用
Author: Yinpei TANG ¹ ; Linjing SHE ¹ ; Zhengwang ZHU ² ; Bing WANG ³ ; Pingsheng ZHU ¹
Author Information

1. The First Clinical Medical College of Henan University of Chinese Medicine， Zhengzhou 450046， China
2. Department of Gastroenterology， The Third Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450008， China
3. Department of Traditional Chinese Medicine， Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine， Shanghai 200240， China
Publication Type:Review
Keywords: Cholestasis; Oxidative Stress; Traditional Chinese Drugs
From: Journal of Clinical Hepatology 2026;42(5):1229-1235
CountryChina
Language:Chinese
Abstract: Cholestatic liver injury （CLI） is a hepatic disorder characterized by the abnormal accumulation of bile acids in the body due to various etiologies， and without timely intervention， it can progress to liver fibrosis， liver cirrhosis， and liver failure and even lead to death. Studies have shown that modulating oxidative stress can alleviate lipid peroxidation and cellular damage， thereby suppressing inflammation and cell apoptosis. In recent years， remarkable progress has been made regarding the active components and compound prescriptions of traditional Chinese medicine in the treatment of CLI by regulating oxidative stress. This article systematically reviews the current status of research on the mechanism of action and clinical application of traditional Chinese medicine in the treatment of CLI by regulating oxidative stress.