Selection strategies and future perspectives for animal models of gastroesophageal varices
- VernacularTitle:食管胃静脉曲张动物模型的选择策略与展望
- Author:
Tianfu LYU
1
;
Qiong NAN
1
;
Ying ZHAO
1
;
Xiaohua WANG
2
;
Ninghui MU
2
;
Bingtuan LU
2
Author Information
- Publication Type:Review
- Keywords: Esophageal and Gastric Varices; Models， Animal; Portal Hypertension
- From: Journal of Clinical Hepatology 2026;42(5):1185-1191
- CountryChina
- Language:Chinese
- Abstract: Gastroesophageal varices （GOV） bleeding is a severe complication of portal hypertension with a high mortality rate. Animal models are indispensable tools for investigating its pathogenesis and developing novel therapeutic strategies. This article systematically reviews the methods for establishing various GOV models， with a particular focus on their efficacy in simulating the key pathological processes such as an increase in hepatic venous pressure gradient and the risk of bleeding， and it also proposes targeted strategies for model selection. Finally， this article discusses the application prospects of emerging techniques in the era of precision medicine， such as organoids and gene editing， in order to provide model selection and a theoretical reference for exploring the mechanism and clinical translation of GOV.
