Practice and analysis of the simplified oral premedication protocol with paclitaxel liposome in patients of advanced gastric cancer
10.12206/j.issn.2097-2024.202406047
- VernacularTitle:晚期胃癌患者紫杉醇脂质体简化口服预处理方案的实践及分析
- Author:
Ling ZHONG
1
;
Jinfa CAO
2
;
Miao HE
3
;
Jing TIAN
4
Author Information
1. Department of Pharmacy, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China;Department of Pharmacy, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, China.
2. Department of Pharmacy, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China;Department of Pharmacy, Taikang Tongji （Wuhan） Hospital, Wuhan 430050, China.
3. Department of Pharmacy, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China.
4. Department of Pharmacy, Naval Medical Center of PLA, Naval Medical University, Shanghai 200052, China.
- Publication Type:Medicine&Clinical
- Keywords:
paclitaxel liposome;
premedication protocol;
simplified;
hypersensitivity reactions;
oral
- From:
Journal of Pharmaceutical Practice and Service
2026;44(6):313-316
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore a feasible simplified premedication protocol for preventing hypersensitivity reactions to taxanes. Methods The electronic medical record system was used to search for data from 49 patients with advanced gastric cancer who received paclitaxel liposome treatment for the first time in the gastroenterology department of Shanghai Changhai Hospital from 2021-06-01 to 2024-06-30, including premedication protocols, allergic reactions, and other adverse reactions. Results Among 31 patients, the premedication regimen included oral dexamethasone 9 mg at 12 h and 6 h prior to liposomal paclitaxel, plus oral loratadine 10 mg and oral ranitidine 150 mg at 12 h prior to treatment. Among 18 patients, the regimen included oral dexamethasone 9 mg at 12 h and 6 h prior to treatment, and oral loratadine 10 mg at 12 h prior to treatment. None of the patients experienced allergic reactions. The incidence of other adverse reactions did not differ significantly between the two groups（P>0.05）. Conclusion Based on literature and practice, a dual simplified premedication protocol of oral corticosteroids（GC）combined with oral H1 receptor blockers（H1RA）was proposed, which provided a new idea for doctors. Further clinical studies are needed to verify its effectiveness.
