Research progress on the effects and mechanisms of plateau hypoxia on drug metabolism
10.12206/j.issn.2097-2024.202403018
- VernacularTitle:高原低氧对药物代谢的影响及机制研究进展
- Author:
Qian LI
1
;
Rong WANG
2
;
Feng YANG
3
;
Xiaofeng WANG
3
;
Dongfeng YIN
3
Author Information
1. School of Pharmacy, Xinjiang Medical University, Urumqi 830000, China;General Hospital of Xinjiang Military Command, Urumqi 830000, China.
2. School of Pharmacy, Xinjiang Medical University, Urumqi 830000, China.
3. General Hospital of Xinjiang Military Command, Urumqi 830000, China.
- Publication Type:Reviews
- Keywords:
plateau;
hypoxia;
drug metabolism;
drug metabolising enzymes;
gut flora
- From:
Journal of Pharmaceutical Practice and Service
2026;44(6):275-279
- CountryChina
- Language:Chinese
-
Abstract:
The plateau region is known for its unique environmental characteristics of low oxygen, low pressure, strong radiation, cold and dryness. Under the low oxygen environment, human physiological functions and drug metabolism are significantly affected. In order to gain a deeper understanding of drug metabolism in the plateau hypoxic environment and to guide the rational use of drugs in the plateau region, the effects of plateau hypoxia on drug metabolism were reviewed in this paper, which focused on changes in metabolic profiles, enzyme activity and expression, and probed the relevant mechanisms in depth.
