A multimodal approach to early detection of anthracycline‑induced cardiotoxicity:complementary roles of left ventricular global longitudinal strain, left atrial reservoir strain, and high‑sensitivity troponin I
10.1186/s44348-026-00071-y
- Author:
Ahmet Ferhat KAYA
1
;
Mehmet ÖZBEK
Author Information
1. Department of Cardiology, Van Regional Education and Research Hospital, Van, Türkiye
- Publication Type:EDITORIAL
- From:
Journal of Cardiovascular Imaging
2026;34(1):9-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:Anthracycline-based chemotherapy is highly effective in breast cancer treatment but is limited by dose-dependent cardiotoxicity. Early identification of subclinical myocardial injury is crucial to prevent progression to irreversible dysfunction.
Objectives:To evaluate whether a multimodal surveillance strategy integrating left ventricular global longitudinal strain (LVGLS), left atrial reservoir strain (LASr), and high-sensitivity troponin I (hs-TnI) can predict early anthracyclineinduced cardiotoxicity.
Methods:This retrospective cohort study included 50 female breast cancer patients (mean age 49.3 ± 8.5 years) treated between January 2022 and December 2024. Echocardiography and biomarkers were assessed at baseline and 1 month after chemotherapy. Cardiotoxicity was defined as a > 10% reduction in LVEF to < 53%.
Results:Cardiotoxicity occurred in 15 patients (30%). LVGLS, LASr, and hs-TnI significantly changed (all P < 0.001).Independent predictors were LVGLS (aOR 1.33), LASr (aOR 0.77), and hs-TnI (aOR 1.07). hs-TnI showed the highest discriminative ability (AUC 0.940).
Conclusions:LVGLS, LASr, and hs-TnI provide complementary information for early detection of cardiotoxicity.
