Donor-to-recipient sex match status has no prognostic effect on long-term survival following liver transplantation:a retrospective observational study
- Author:
Woo-Hyoung KANG
1
;
I-Ji JEONG
;
Shin HWANG
;
Chul-Soo AHN
;
Deok-Bog MOON
;
Tae-Yong HA
;
Gi-Won SONG
;
Dong-Hwan JUNG
;
Gil-Chun PARK
;
Young-In YOON
;
Sung-Gyu LEE
Author Information
- Publication Type:Original Article
- From: Clinical Transplantation and Research 2026;40(1):76-86
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:Studies on whether donor-to-recipient sex match status affects long-term survival after liver transplantation (LT) have yielded contradictory results. This study evaluated whether donor-to-recipient sex match status influenced long-term survival after living donor liver transplantation (LDLT) or deceased donor liver transplantation (DDLT) at a high-volume center.
Methods:The study included 6,664 patients who underwent primary LT between January 2000 and December 2022 at our institution. Patients were divided into four groups according to donor-to-recipient sex match status: male-to-male (n=3,427 [51.4%]), male-to-female (n=1,152 [17.3%]), female-to-male (n=1,385 [20.8%]), and female-to-female (n=700 [10.5%]).
Results:Regarding clinical characteristics, the four groups differed significantly regarding background liver disease (P<0.001), model for end-stage liver disease score (P<0.001), serum protein induced by vitamin K absence or antagonist II level (P=0.003), presence of concurrent hepatocellular carcinoma (HCC; P<0.001), and type of LT (P=0.003). Overall survival (OS) of all LT recipients did not differ significantly among the groups (P=0.377). Donor-to-recipient sex match status did not affect long-term OS in either LDLT (P=0.176) or DDLT (P=0.220) groups. In addition, sex match status did not significantly influence posttransplant OS among patients who underwent LDLT without HCC (P=0.464), LDLT with HCC (P=0.236), DDLT without HCC (P=0.338), or DDLT with HCC (P=0.818).
Conclusions:Donor-to-recipient sex match status does not significantly affect posttransplant patient survival or HCC prognosis after LDLT or DDLT.
