Efficacy of Submucosal Polydeoxyribonucleotide Injection after Impacted Mandibular Third Molar Extraction: A Randomized Controlled Trial
- Author:
Hyun Joong KIM
1
;
Seo Yeon PARK
;
Hyungjin KWON
;
Yiqin FANG
;
Youngmin KWON
;
Chunui LEE
Author Information
- Publication Type:Original Article
- From:Yonsei Medical Journal 2026;67(1):79-86
- CountryRepublic of Korea
- Language:English
-
Abstract:
Purpose:This study aimed to evaluate the efficacy of polydeoxyribonucleotide (PDRN) injection after impacted mandibular third molar (IMTM) extraction. The primary outcome was postoperative pain, while secondary outcomes included postoperative swelling, periodontal pocket depth, and patient-reported outcome.
Materials and Methods:Thirty medically uncompromised patients who underwent bilateral extraction of IMTMs were enrolled in the clinical study. PDRN was randomly injected on the experimental side, while normal saline was injected on the control side.Postoperative pain was assessed using a visual analog scale. Postoperative swelling was evaluated via linear measurements based on the Laskin method. Furthermore, three-dimensional volumetric analysis was conducted by superimposing serial facial scans obtained at baseline (preoperatively) and on postoperative days 3 and 7. Pocket probing depth was evaluated using a periodontal probe. Patients’ postoperative morbidity and subjective perceptions were evaluated using the patient-centered outcome questionnaire. Statistical software was used to evaluate the data, and p<0.05 was considered statistically significant.
Results:Patients demonstrated statistically meaningful reductions in postoperative pain, swelling, and discomfort on the experimental side.
Conclusion:The results suggest that PDRN injection can be a suitable option to mitigate postoperative complications after IMTM extraction. However, further randomized controlled trials are required to confirm the reliability of the study and verify its suitability.
