Multivariate and multi-trait analyses in psychiatric genetics: A narrative review of tools, challenges, and future directions
- Author:
Shin-Won LIM
1
;
Hyun Seok DO
;
Soyeon KIM
;
Woojae MYUNG
Author Information
- Publication Type:Review Article
- From: Precision and Future Medicine 2025;9(4):181-196
- CountryRepublic of Korea
- Language:English
- Abstract: Psychiatric disorders exhibit complex genetic characteristics such as substantial polygenicity, pleiotropy, and genetic overlap, making them difficult to fully understand through studies focused solely on single genes or individual diseases. This review underscores the importance of multivariate and multi-trait analyses in psychiatric genetics and provides a comprehensive overview of major analytical tools, including their concepts, strengths, limitations, and applications. By addressing the current methodological challenges and proposing future directions, we aim to advance our understanding of the genetic architecture underlying psychiatric disorders and support progress towards precision medicine.
