Adenosine receptors activate cyclic adenosine monophosphate signaling in salivary gland cells
10.11620/IJOB.2025.50.1.31
- Author:
Ji-Ah KANG
1
;
Yoo-Bin KIM
;
Sunghan LEE
;
Hee-Kyung PARK
;
Se-Young CHOI
Author Information
1. Department of Physiology, Dental Research Institute, Seoul National University School of Dentistry, Seoul 03080, Republic of Korea
- Publication Type:Original Article
- From:International Journal of Oral Biology
2025;50(1):31-39
- CountryRepublic of Korea
- Language:English
-
Abstract:
Sympathetic innervation stimulates β-adrenergic receptors, triggering cyclic adenosine monophosphate (cAMP) production and enhancing protein secretion in salivary gland cells. While cAMP signaling, in conjunction with Ca 2+ signaling, is essential for salivary gland function, the identified cAMP-producing G-protein-coupled receptors (GPCRs) remains limited. Here, we report the presence of cAMP-producing adenosine receptors in salivary gland cells. By reanalyzing publicly available single-cell transcriptome datasets of human and mouse submandibular glands, we identified mRNA expression of adenosine A1, A2A, A2B, and A3 receptors. Additionally, we confirmed that 5’-N-ethylcarboxamidoadenosine (NECA), an adenosine A2B receptor agonist, increases cAMP levels in human salivary gland cells, suggesting a physiological role for adenosine A2B receptors. Our findings enhance understanding of adenosine’s regulatory function in salivary glands and highlight new avenues for research on cAMPproducing adenosine receptors.
