Primary Hepatic Mucosa-Associated Lymphoid Tissue Lymphoma: A Case Report and Literature Review
10.18525/cu.2025.10.2.119
- Author:
Sook Hyun SHIN
1
;
Jeong-Ju YOO
;
Sang Gyune KIM
;
Young Seok KIM
;
Susie CHIN
Author Information
1. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea
- Publication Type:Case Report
- From:
Clinical Ultrasound
2025;10(2):119-128
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma is an extremely rare extranodal marginal zone B-cell lymphoma, with non-specific clinical and radiologic features, making diagnosis challenging. We report a 20-year-old female with chronic hepatitis B who presented with a heterogeneously hypoechoic hepatic mass on ultrasound. Further evaluation with contrast-enhanced ultrasound, computed tomography, and magnetic resonance imaging revealed a solitary lesion with characteristic enhancement patterns and diffusion restriction. Ultrasound-guided biopsy confirmed MALT lymphoma. Literature review indicates that chronic inflammation, viral infection, and genetic abnormalities may contribute to its pathogenesis. Treatment approaches vary, including surgical resection, liver transplantation, chemotherapy, radiotherapy, and rituximab, reflecting the absence of standardized guidelines. Despite diagnostic difficulties, primary hepatic MALT lymphoma generally exhibits an indolent course and favorable prognosis. Early recognition and histopathologic confirmation are essential, and management should be individualized based on tumor characteristics and patient factors.
