Single-Cell Transcriptomics Applications in Musculoskeletal Regenerative Medicine:from Technology to Therapeutic Translation
- Author:
Yongjin AHN
1
Author Information
- Publication Type:Review Article
- From: Clinical Pain 2025;24(1):39-46
- CountryRepublic of Korea
- Language:English
- Abstract: The advent of single-cell transcriptomics marked a paradigm shift in biology, enabling in-depth analysis of cellular heterogeneity and molecular mechanisms at a previously unachievable resolution. Single-cell transcriptomics has revealed previously unrecognized subpopulations, rare cell types, transitional states, and molecular signatures. Many of these novel insights have been successfully translated to therapeutic applications. This review examines the brief history and computational strategies involved in the single-cell transcriptomics technique, as well as the applications of single-cell transcriptomics in musculoskeletal regenerative medicine, focusing on recent discoveries in bone, cartilage, muscle, and tendon biology. Key findings include identification of novel progenitor populations, differentiation pathways, and insights into disease mechanisms. We discuss how single-cell transcriptomics is making breakthroughs in therapeutic strategies through improved understanding of regenerative processes and cellular dynamics.
