Non-Pharmacological Treatment of CRPS (Rehabilitation and Graded Motor Imagery Training)
- Author:
Kyung Eun NAM
1
Author Information
- Publication Type:Review Article
- From: Clinical Pain 2025;24(1):51-56
- CountryRepublic of Korea
- Language:English
- Abstract: Complex regional pain syndrome (CRPS) is characterized by disproportionate pain and various sensorimotor and autonomic symptoms following trauma or surgery. The pathophysiology remains unclear but involves neurogenic inflammation, autonomic dysfunction, and maladaptive central nervous system plasticity. A multimodal and interdisciplinary approach is essential due to the heterogeneous nature of CRPS symptoms and mechanisms. Rehabilitation strategies commonly incorporate patient education, exercise interventions such as range of motion exercises and functional training, sensorimotor interventions including mirror therapy and graded motor imagery, and physiotherapy. Sensorimotor training shows promise in addressing maladaptive neuroplastic changes. Although current evidence is limited by small sample sizes and heterogeneity, meta-analyses suggest beneficial effects on pain and function. Physiotherapy and occupational therapy also play roles in preventing disuse and restoring function, despite mixed evidence regarding their efficacy. Overall, rehabilitation for CRPS demands the integration of multiple intervention methods for optimal outcomes and calls for further well-design, large scale investigation to prove their efficacy.
