Associated factors of osteoporosis and the impact of osteoporosis on all-cause mortality in incident hemodialysis older patients
- Author:
Seunghye LEE
1
;
Yoomee KANG
;
Yu Ah HONG
;
Sung Joon SHIN
;
Soon Hyo KWON
;
Sungjin CHUNG
;
Young Youl HYUN
;
Sang Heon SONG
;
Jae Won YANG
;
Won Min HWANG
;
Jang-Hee CHO
;
Kyung Don YOO
;
In O SUN
;
Gang-Jee KO
;
Byung Chul YU
;
Hyunsuk KIM
;
Woo Yeong PARK
;
Tae Won LEE
;
Dong Jun PARK
;
Eunjin BAE
;
Author Information
- Publication Type:Original Article
- From:Kidney Research and Clinical Practice 2026;45(1):110-119
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:With the aging population and advancements in medical care worldwide, the number of older patients with end-stage kidney disease continues to rise. This study aimed to identify factors associated with osteoporosis and osteopenia in older patients undergoing incident hemodialysis and assess their impact on mortality.
Methods:We analyzed a large multicenter retrospective cohort of patients aged ≥70 years undergoing incident hemodialysis to identify factors associated with osteoporosis using logistic regression analysis and to assess the association of death with osteoporosis and osteopenia using Cox multivariable analysis.
Results:Among 710 patients, 39.0% and 19.6% had osteoporosis and osteopenia, respectively. Osteoporosis was significantly associated with female sex, a history of fractures, and the absence of phosphate binder use. During a median follow-up of 36.8 months, 348 participants (58.8%) died. Mortality rates were the highest in the osteoporosis group (79.8%), followed by the osteopenia (77.2%) and normal bone mineral density (BMD) groups (35.2%). Cox regression analysis revealed that even after adjusting for covariates, the osteoporosis group was significantly associated with a higher mortality risk than the normal BMD group. Osteoporosis at the start of hemodialysis was significantly associated with higher mortality.
Conclusion:We should consider the importance of bone health in patients undergoing incident hemodialysis and pay attention to the use of phosphate binders and fracture prevention.
