Renal fibrosis: research progress on mechanisms and therapeutic strategies
- Author:
Cheng-Xiao YIN
1
;
Jia-Rui FAN
;
Xiao-Gang DU
Author Information
- Publication Type:Review Article
- From:Kidney Research and Clinical Practice 2026;45(1):22-35
- CountryRepublic of Korea
- Language:English
- Abstract: Renal fibrosis (RF) is a prevalent clinical symptom of numerous chronic kidney illnesses and a significant pathological alteration in end-stage renal disease resulting from various mechanisms, such as abnormally activated signaling pathways, microRNAs, aging, autophagy disorders, and fibrotic ecological niches, all of which contribute to RF development. Inhibiting, blocking, or delaying the aforementioned mechanisms may yield novel approaches for treating RF. This article explores advancements in the comprehension of the mechanisms and therapeutic approaches for RF.
