A Case of Neurogenic Myopathy in a Shih-Tzu:Clinical, Diagnostic and Histopathological Findings

Author: Munso KIM ¹ ; Joon Woo LEE ; Jihu KIM ; Hyeona BAE ; DoHyeon YU ; Hyomi JANG ; Dong-In JUNG
Author Information

1. College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, South Korea
Publication Type:Case Report
From: Journal of Veterinary Clinics 2025;42(4):196-201
CountryRepublic of Korea
Language:English
Abstract: A 7-year-old neutered male Shih Tzu presented with acute onset of progressive tetraparesis and generalized muscle atrophy. Neurological examination, electromyography (EMG), and muscle biopsy revealed findings consistent with denervation-induced muscular atrophy. Based on these results, a tentative diagnosis of immune-mediated neurogenic myopathy was established. Immunosuppressive therapy with cyclosporine and mycophenolate mofetil led to a marked clinical improvement. However, relapse following discontinuation of therapy indicated the chronic relapsing nature of the disease. This case demonstrates the diagnostic value of EMG and muscle biopsy in identifying neuromuscular disorders and underscores the importance of a multimodal diagnostic approach for the accurate diagnosis and management of suspected neurogenic myopathies.