A Case of Canine Mammary Comedocarcinoma with Regulatory T Cell Infiltration
10.17555/jvc.2024.41.4.215
- Author:
Siwon JEONG
1
;
Jiwoong YOON
;
Woo-Jin SONG
;
Jongtae CHEONG
;
Young-min YUN
;
Gee Euhn CHOI
;
Myung-Chul KIM
Author Information
1. College of Veterinary Medicine, Jeju National University, Jeju 63243, Korea
- Publication Type:Case Report
- From:
Journal of Veterinary Clinics
2024;41(4):215-222
- CountryRepublic of Korea
- Language:English
-
Abstract:
An adult female dog was presented for evaluation of rapid growth of mammary gland masses. Complete blood count, serum biochemistry, and diagnostic imaging results were unremarkable. Fine needle aspirates of the mammary masses indicated mammary carcinoma characterized by large globoid cells with finely granular eosinophilic globules or Melamed-Wolinska-like bodies. A regional mastectomy was performed on the masses. Subsequent histopathologic examination of the surgically resected masses resulted in a diagnosis of mammary comedocarcinoma with nodal metastasis and distinct perivascular immune infiltrates, which were subject to immunohistochemical and flow cytometric immunophenotyping. Immunohistochemical examination confirmed the infiltration of CD3 + T and PAX5 + B lymphocytes. Flow cytometric analysis demonstrated tumor-infiltrating CD4 + CD25 + FOXP3 + regulatory T, CD8 + T, CD11b + myeloid, and CD21 + B cells. Of note, paired flow cytometric analysis of peripheral blood and tumor tissues showed a preferential tumor infiltration of regulatory T and B cells. Approximately two months after the mastectomy, the tumor reoccurred at the surgery site. The dog died due to deteriorating conditions. We report a rare case of canine mammary comedocarcinoma, providing clinical, clinicopathologic, histologic, and immunophenotypic characteristics. Our case is valuable in providing a rationale for basic research that maps the immune landscape of mammary comedocarcinoma to identify key immune subsets for cancer progression.
