Successful Treatment of Feline Nasopharyngeal Lymphoma by Hypofractionated Radiation Therapy After Surgical Debulking in a Cat
10.17555/jvc.2024.41.2.117
- Author:
Sumin KIM
1
;
Gunha HWANG
;
Jin-Yoo KIM
;
Chi-Oh YUN
;
Seunghwa LEE
;
Moonyeong CHOI
;
Joong-Hyun SONG
;
Hee Chun LEE
;
Tae Sung HWANG
Author Information
1. Institute of Animal Medicine, Department of Veterinary Medicine Imaging, College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Korea
- Publication Type:Case Report
- From:
Journal of Veterinary Clinics
2024;41(2):117-122
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 3-year-old spayed female Russian blue cat was presented for dyspnea, nasal discharge, and stertorous breathing. Plain thoracic radiography revealed no specific findings. Computed tomography (CT) was performed to differentiate upper airway tract disorders. It revealed the presence of an iso-attenuating mass measuring 10.0 × 7.9 × 15.6 mm, with mild homogeneous contrast enhancement occupying the rostral nasopharynx. The mass was surgically debulked via a longitudinal incision in the soft palate. Histopathological and immunohistochemistry analysis of the surgically excised mass revealed CD3–/ CD79a+ B cell lymphoma with an incomplete margin. The patient underwent hypofractionated radiation therapy, receiving a total of 36 Gray (Gy) in 6 Gy fractions over a six-week period. A follow-up CT examination was performed after 27 months of irradiation and the patient was confirmed to have achieved a complete response. There were no complications related to irradiation. The patient was alive for 40 months without recurrence. This study suggests that hypofractionated radiation therapy combined with surgical debulking could be considered as a treatment option for feline nasopharyngeal lymphoma.
