Behavioral and Psychological Symptoms and Instrumental Activities of Daily Living in Patients With Mild Cognitive Impairment
10.22802/jksbtp.2026.32.1.37
- Author:
Il-Seon SHIN
;
Min JHON
;
Seon-Young KIM
;
Hee-Young SHIN
;
Ju-Yeon LEE
;
Sung-Wan KIM
;
Jae-Min KIM
- Publication Type:Original Articles
- From:
Journal of the Korean Society of Biological Therapies in Psychiatry
2026;32(1):37-43
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objectives:This study aimed to investigate the impact of behavioral and psychological symptoms (BPS), assessed by the neuropsychiatric inventory (NPI) total score, on instrumental activities of daily living (IADL) performance in patients with mild cognitive impairment.
Methods:Ninety-two patients diagnosed with mild cognitive impairment who visited a university hospital dementia clinic were recruited. Assessments included the Korean version-Mini Mental State Examination, NPI, Korean-IADL (KIADL), and Short Form of Geriatric Depression Scale-Korean version. Correlation and hierarchical multiple regression analyses were performed to analyze the relationship between BPS and IADL.
Results:The mean age of participants was 74.61±5.86 years. K-IADL scores significantly correlated with age (r=0.347, p<0.001) and NPI total score (r=0.265, p<0.05). Hierarchical regression analysis showed that the addition of the NPI total score significantly increased the explained variance of functional decline (R 2 =0.197, F=5.332, p<0.001), with age (β=0.354, p<0.001) and NPI total score (β=0.248, p<0.05) identified as independent predictors in patients with mild cognitive impairment.
Conclusions:The overall severity of BPS exerts a detrimental effect on IADL function in mild cognitive impairment patients, independent of age and cognitive status. These results underscore the clinical importance of evaluating the cumulative burden of BPS to predict functional prognosis and implement early interventions.
