Mind-Brain-Immune Interactions After Transplantation:A Psychoneuroimmunology-Informed Review
10.22802/jksbtp.2026.32.1.14
- Author:
Saeheon JANG
1
Author Information
1. Department of Psychiatry, Bongseng Memorial Hospital, Busan, Korea
- Publication Type:Reviews
- From:
Journal of the Korean Society of Biological Therapies in Psychiatry
2026;32(1):14-25
- CountryRepublic of Korea
- Language:English
-
Abstract:
Organ transplantation significantly improves survival and quality of life for patients with end-stage organ failure. However, the profound physical and psychological stress and immunological changes surrounding transplantation critically influence mental health and clinical outcomes. Psychoneuroimmunology, the interdisciplinary study of interactions among the central nervous, endocrine, and immune systems, offers an essential framework for understanding and addressing the psychological, social, and biological challenges faced by transplant recipients. This review synthesizes current evidence on the fundamental mechanisms of psychoneuroimmunology, post-transplant mental health issues, psychosocial impacts, and integrated clinical interventions, with particular attention to identity transformation, family and social relationships, cultural and economic factors, resilience, and social support. By linking these domains to psychoneuroimmunology mechanisms, we highlight the necessity of a biopsychosocial approach to optimize both mental health and immune stability in transplant care.
