Psychodynamic Psychopharmacological Approach in Treatment-Resistant Depression
10.22802/jksbtp.2025.31.2.40
- Author:
Seoyoung JANG
;
Jungmin WOO
- Publication Type:Reviews
- From:
Journal of the Korean Society of Biological Therapies in Psychiatry
2025;31(2):40-46
- CountryRepublic of Korea
- Language:English
-
Abstract:
Depression remains a major public health challenge, particularly when it becomes treatment-resistant. The development and recovery of depression involve complex interactions among biopsychosocial factors. While the treatment of depression is comprehensive, treatment-resistant depression (TRD) often leans heavily on biological interventions. This review advocates for an integrated approach combining pharmacotherapy and psychotherapy, introducing psychodynamic psychopharmacology as a promising alternative. This strategy aims to enhance treatment outcomes by addressing treatment resistance-related psychodynamic factors and fostering a therapeutic alliance. Notably, the framework categorizing treatment resistance into two types and outlining specific management principles holds practical applicability. Investigating this integrated approach may not only deepen our understanding of TRD but also broaden therapeutic options for clinicians.
