Survival Rates of Patients with Gastric Cancer According to Age and Sex: A Large-Scale Study Using Data from 14,739 Patients
- Author:
Yonghoon CHOI
1
;
Nayoung KIM
;
Ji Hyun KIM
;
Hyeong Ho JO
;
Hyeon Jeong OH
;
Hye Seung LEE
;
Yu Kyung JUN
;
Hyuk YOON
;
Cheol Min SHIN
;
Young Soo PARK
;
Dong Ho LEE
;
So Hyun KANG
;
Young Suk PARK
;
Sang-Hoon AHN
;
Yun-Suhk SUH
;
Do Joong PARK
;
Hyung Ho KIM
;
Ji-Won KIM
;
Jin Won KIM
;
Keun-Wook LEE
;
Won CHANG
;
Yoon Jin LEE
;
Kyoung Ho LEE
;
Young Hoon KIM
Author Information
- Publication Type:Original Article
- From:Cancer Research and Treatment 2026;58(1):252-263
- CountryRepublic of Korea
- Language:English
-
Abstract:
Purpose:The male predominance in the incidence of gastric cancer (GC) is established; however, sex differences in the prognosis of GC remain controversial. As such, this study analyzed the prognosis of patients with GC based on age and sex.
Materials and Methods:Data from 14,739 patients diagnosed with GC at Seoul National University Bundang Hospital between 2003 and 2023 were analyzed. Baseline characteristics, histological types of GC, overall and GC-specific survival rates (age and stage stratification), and associated risk factors were analyzed.
Results:Females were significantly younger (p < 0.001) and exhibited more gastric body cancers (p < 0.001) and tumors with diffuse-type or poorly differentiated histology (p < 0.001) than males. Females exhibited an advantage over males in terms of overall survival (p=0.004), but not in GC-specific survival. However, age stratification revealed significant sex differences, that females < 50 years of age exhibited survival disadvantages (p < 0.001); however, this trend was reversed with age, and females > 60 years exhibited survival advantages (p < 0.001) for both overall and GC-specific survival. This may be explained by the lower ratio of diffuse-type GC as females age. Furthermore, in the analysis according to stage, females with stage IV disease exhibited significant survival disadvantages, with significantly younger age and a higher proportion of diffuse-type GC which exhibits aggressive features, resulting in poorer survival than in males.
Conclusion:Age and stage stratification revealed significant differences in survival between the sexes, which can be helpful for public health strategies.
