Cell‑based artificial platelet production:historical milestones, emerging trends, and future directions
10.1007/s44313-025-00071-9
- Author:
Kyoung Mi KIM
;
Koudai I. ALBAIRA
;
Jayoung KANG
;
Yong Gon CHO
;
Soon Sung KWON
;
Jaecheol LEE
;
Dae‑Hyun KO
;
Sinyoung KIM
;
Seung Yeob LEE
- Publication Type:REVIEW
- From:Blood Research
2025;60():32-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Cell-based artificial platelet production has made remarkable progress over the past three decades, driven by the need for safe and stable platelet sources in the face of donor limitations and transfusion-related risks. This review provides a chronological overview of the evolution of in vitro platelet production from various cell sources (CD34+ hematopoietic stem cells, embryonic stem cells, induced pluripotent stem cells (iPSCs), and others) and highlights key advances in the field. We outline developments from the foundational experiments of the 1990s, through the introduction of iPSCs in the mid-2000s, to the adoption of three-dimensional culture and bioreactor technologies in the late 2010s and the emergence of clinical trials in the 2020s. In addition, we discuss future perspec‑ tives, including the role of advanced gene editing and scalable biomanufacturing technologies in accelerating clinical translation. This comprehensive review underscores the promise of artificial platelet production technologies for clini‑ cal applications and discusses the remaining challenges, such as scalability, cost-effectiveness, and regulatory hurdles.The recent completion of the first human clinical trials using iPSC-derived platelets marks a significant milestone, pointing to a future in which patient-specific or human leukocyte antigen-universal platelets may be transformed into transfusion medicine and regenerative therapies.
