Treatment of older patients with Hodgkin lymphoma
10.1007/s44313-025-00084-4
- Author:
Chung Hyun PARK
;
Hyunsoo CHO
;
Soo‑Jeong KIM
- Publication Type:REVIEW
- From:Blood Research
2025;60():35-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Older patients with classic Hodgkin lymphoma (HL) often experience poor outcomes due to age-related comor‑ bidities and treatment-related toxicity. Comprehensive geriatric assessment and supportive care measures, includ‑ ing pre-phase corticosteroids, growth factor prophylaxis, and organ function monitoring, are essential for optimizing treatment tolerance in this vulnerable patient population. Recent phase III trial (S1826) demonstrated that nivolumab plus doxorubicin, vinblastine, and dacarbazine (Nivo + AVD) significantly improves progression-free survival and is bet‑ ter tolerated than brentuximab vedotin (BV) + AVD, particularly in patients over 60 years of age. Given its efficacy and reduced toxicity, Nivo + AVD is likely to become a key treatment option for fit older patients with HL. For frail patients, chemo-free approaches with BV and checkpoint inhibitors remain viable alternatives. Future research should refine fitness-based treatment strategies, integrate novel agents, and enhance supportive care to improve outcomes and minimize treatment-related toxicity in this population.
