Polyglycolic acid-cyanoacrylate complex for prevention of major intestinal anastomotic leakage in a rat model:an experimental animal study
10.4174/astr.2025.109.5.335
- Author:
Chinock CHEONG
1
;
Hyun Myung DOO
;
YeonUk JU
;
Jun-Woo BONG
;
Sang-Hee KANG
;
Sun-Il LEE
;
Byung Wook MIN
;
You-Jin JANG
;
Won Jun SEO
;
Jong-Han KIM
Author Information
1. Division of Colorectal Surgery, Department of Surgery, Korea University College of Medicine, Seoul, Korea
- Publication Type:ORIGINAL ARTICLE
- From:Annals of Surgical Treatment and Research
2025;109(5):335-343
- CountryRepublic of Korea
- Language:English
-
Abstract:
Purpose:Various materials and techniques have been explored to prevent anastomotic leakage (AL). Polyglycolic acid (PGA) sheets and cyanoacrylate (CA) glue have been investigated for their potential in wound healing and fistula closure. This study aims to assess the feasibility of PGA-CA complex (PCC) to prevent AL by developing a major leakage model in rats.
Methods:After the creation of the major leakage model in the jejunum of rat, the leakage site was treated with each material individually and in combination. Rats were categorized into the control, CA, PGA, and PCC groups.
Results:A total of 40 rats were included, with one animal from the CA and PGA groups having expired. Gross intraabdominal conditions showed no significant difference between the groups. Median intraluminal bursting pressure was 120.0 (range, 102.5–138.0) in the CA group and 138.0 (range, 127.0–147.0) in the PCC group (P = 0.286). Pathologic evaluation revealed fibroblast activation was significantly different in the PCC group (P = 0.025).
Conclusion:No significant differences were observed in the macroscopic intra-abdominal findings or intraluminal bursting pressure between the groups. The only difference in PCC group was enhanced fibroblast activation at moderate levels compare to the control group. Further research is warranted to optimize material combinations and validate efficacy in larger preclinical and clinical settings.
