Rhamnogalacturonan rich fractions isolated from Saururus chinensis alleviate ulcerative colitis via regulation of MAPK/NF-κB pathway and tight junction
- Author:
Tae Eun KIM
1
;
Seung-U SON
;
YangKook RHO
;
Kwang-Soon SHIN
Author Information
- Publication Type:Research Paper
- From:Nutrition Research and Practice 2026;20(2):182-200
- CountryRepublic of Korea
- Language:English
-
Abstract:
RESULTS:The SCPE-II was characterized as a typical RG type polysaccharide. In addition, tight junction (TJ) imbalance and inflammatory cytokines in IL-1β-induced inflammatory epithelial cells was inhibited by SCPE-II. Moreover, SCPE-II suppressed various clinical symptoms in DSS-induced UC mice. These preventive effects were strongly correlated with the regulation of inflammatory cytokine, immunoglobulin, mitogen-activated protein kinase, nuclear factor kappa B, TJ, short chain fatty acid.
CONCLUSION:Consequently, the present finding strongly suggests that SCPE-II isolated from S. chinensis is an effective ingredient for preventing UC.
