Nitric Oxide Production Inhibitory Terpenylated Coumarins from Ailanthus altissima
- Author:
Beom Kyun AN
1
;
Jae Sang HAN
;
Joon Su JANG
;
Yong Beom CHO
;
Mi Kyeong LEE
;
Bang Yeon HWANG
Author Information
- From:Natural Product Sciences 2026;32(1):44-49
- CountryRepublic of Korea
- Language:English
- Abstract: LC-MS/MS-based molecular networking was used to guide the targeted isolation of terpenylated coumarins from the barks of Ailanthus altissima. Five known terpenylated coumarins (1–5), along with two simple coumarins (6 and 7), were isolated from the CH 2 Cl 2 -soluble fraction. Their structures were determined using spectroscopic techniques, including 1D and 2D NMR and LC-HR-MS/MS. Notably, altissimacoumarins C (1), F (3), and H (4) demonstrated potent inhibition of LPS-induced nitric oxide production in RAW 264.7 macrophages, with IC50 values of 36.1, 27.9, and 11.2 μM, respectively. These results demonstrate the antiinflammatory properties of A. altissima, supporting its possible application in treating inflammatory disorders.
