Secondary Metabolites of Hemerocallis fulva var. kwanso Regel and Their PTP1B Inhibitory Potential
10.20307ps.2026.32.1.76
- Author:
Thi Thanh LE
;
Manh Tuan HA
;
Trong Trieu TRAN
;
Seung Eui MIN
;
Kang-Hyun HAN
;
Jungmoo HUH
;
Jeong Ah KIM
;
Byung Sun MIN
- From:Natural Product Sciences
2026;32(1):76-83
- CountryRepublic of Korea
- Language:English
-
Abstract:
A phytochemical study of the root extract of Hemerocallis fulva var. kwanso Regel resulted in the isolation and structural characterization of four lignans (1‒4), three flavanones (5, 6, and 8), one chalcone (9), and two monoterpenes (7 and 10). Enzyme inhibition assays revealed that two flavanone glucosides (5 and 6) showed significant inhibitory effect against protein tyrosine phosphatase 1B (PTP1B), with IC50 values of 31.38 µM and 51.46 µM, respectively. Further enzyme kinetic studies demonstrated that these two compounds acted as noncompetitive PTP1B inhibitors, with Ki values of 30.88 µM and 50.38 µM, respectively.
