Clinical translation of mid-infrared quantum cascade laser-based label-free molecular diagnostics and imaging
- Author:
Dong Kun LEE
1
Author Information
- Publication Type:Review article
- From: Medical Lasers 2026;15(1):43-52
- CountryRepublic of Korea
- Language:English
- Abstract: Mid-infrared spectroscopy captures fundamental molecular vibrations, enabling label-free chemical contrast from tissues, cells, and biofluids without the need for dyes or antibodies. Quantum cascade lasers deliver high spectral brightness and narrowband emission in the mid-infrared region, facilitating faster, more compact infrared measurement systems than conventional thermal-source Fourier transform infrared platforms. This review examines the clinical translation of quantum cascade laser-based mid-infrared diagnostics and imaging, emphasizing applications across different sample types, hardware architectures that govern measurement fidelity and speed, and workflow considerations essential for clinical deployment. Principal barriers encompass atmospheric interference from water vapor and carbon dioxide, scattering-related spectral distortions, substrate artifacts, and pre-analytical variability. We outline a comprehensive translation framework that integrates analytical validity, clinical validity, and operational feasibility, addressing practical constraints of turnaround time, staffing, and cost-effectiveness for real-world implementation.
