Eradication of Aspiculuris tetraptera in various immunodeficient mouse models using ivermectin: a case report
10.1186/s42826-025-00263-5
- Author:
Ji-Hun LEE
1
;
Eun-Seon YOO
;
Na-Won KIM
;
Han-Bi JEONG
;
Ah-Reum KANG
;
Sun-Min SEO
;
Young-Jun PARK
;
Byeong-Cheol KANG
;
Yang-Kyu CHOI
Author Information
1. Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 05029, South Korea
- Publication Type:CASE REPORT
- From:Laboratory Animal Research
2026;42(1):82-87
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:Despite advancements in laboratory animal facility management, pinworm infections remain a persistent issue in immunodeficient mouse colonies. Rapid diagnosis and treatment are crucial to mitigating potential scientific and economic consequences. Effective control requires both the administration of anthelmintic agents and rigorous environmental decontamination. However, the safety and efficacy of these treatments in genetically modified mouse models remains uncertain.Case presentation Aspiculuris tetraptera infestation was identified in multiple immunodeficient mouse models housed in a laboratory facility. Diagnosis was confirmed through fecal flotation for egg detection and necropsy for adult worm examination in the large intestines. Mice received three subcutaneous ivermectin injections at two-week intervals, coupled with environmental decontamination using ivermectin spray for four consecutive weeks. Following treatment, all colonies tested negative for A. tetraptera without any mortality.
Conclusions:A combination of subcutaneous ivermectin injection and environmental spray application effectively eradicated A. tetraptera infestation in immunodeficient mouse colonies. The treatment protocol led to the complete elimination of eggs and adult worms, offering a practical strategy for managing pinworm infections in genetically modified mouse models. Limitations include the small sample size, and the lack of a comprehensive evaluation of physiological and metabolic safety in immunodeficient mice. Further validation will be required to confirm the broader applicability of this approach.
