Current Controversies and Insights Surrounding Multiple Evanescent White Dot Syndrome: A Narrative Review
10.21561/jor.2025.10.2.135
- Author:
Yoo-Ri CHUNG
1
;
Kyung Ho LEE
;
Ji Hun SONG
;
Hae Rang KIM
Author Information
1. Department of Ophthalmology, Ajou University School of Medicine, Suwon, Korea
- Publication Type:REVIEW ARTICLE
- From:
Journal of Retina
2025;10(2):135-143
- CountryRepublic of Korea
- Language:English
-
Abstract:
Multiple evanescent white dot syndrome (MEWDS) is a type of chorioretinal inflammatory disorder that primarily affects the outer retina and/or choroid and is categorized under the group of conditions known as ‘white dot syndrome.’ This affliction predominantly occurs in otherwise healthy young-to-middle-aged females and generally follows a benign course with spontaneous recovery. The exact pathogenesis remains unclear, and there is ongoing debate regarding the primary site of inflammation. Associations with systemic conditions, including COVID-19 infection and vaccination, have also been proposed. Additionally, the presence of overlapping or coexisting chorioretinal disorders has led to the concept of ‘secondary MEWDS.’ The recent development of optical coherence tomography angiography provides new imaging features of MEWDS, though its precise role in white dot syndromes remains a topic of discussion. In this review, we focus on these current controversies and insights surrounding MEWDS.
