Bevacizumab in frontline chemotherapy improved the survival outcome for advanced ovarian clear cell carcinoma:a multicenter retrospective analysis
- Author:
Shinichi TATE
1
;
Toshiyuki SEKI
;
Kyoko NISHIKIMI
;
Youichi UNNO
;
Mizue ITOI
;
Sadatomo IKEDA
;
Nobuhisa YOSHIKAWA
;
Hidehiko AKASHI
;
Eitaro SUZUKI
;
Naotake TANAKA
;
Takashi HIRAKAWA
;
Hiroaki KAJIYAMA
;
Hirokuni TAKANO
;
Kosuke YOSHIHARA
;
Kaori KOGA
;
Aikou OKAMOTO
;
Makio SHOZU
Author Information
- Publication Type:Original Article
- From:Journal of Gynecologic Oncology 2025;36(5):e80-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objective:Advanced ovarian clear cell carcinoma (OCCC) is associated with poor outcomes owing to chemoresistance. Bevacizumab (Bev) is increasingly being used to treat advanced ovarian cancer; however, its efficacy in OCCC remains unclear. This study evaluated the treatment outcomes of frontline bevacizumab chemotherapy in patients with OCCC.
Methods:This retrospective multi-institutional study included patients diagnosed with advanced OCCC at eight institutions in Japan between 2008 and 2018. Patients were categorized into pre and post-market groups based on the Bev approval dates. Progressionfree survival (PFS) and overall survival (OS) were analyzed using univariate and multivariate methods. Additionally, patients were classified into Bev-treated (Bev+) and non-Bev-treated (Bev−) groups, and their prognoses were compared.
Results:A total of 96 patients were in the pre-market group and 82 in the post-market group. The post-market group had a significantly higher proportion of patients with poor performance status and patients who underwent interval debulking surgery (p<0.01 and p<0.01, respectively). Univariate analysis demonstrated a better PFS in the post-market group (p=0.041). In multivariate analysis, better PFS (hazard ratio [HR]=0.52; p=0.002) and OS (HR=0.47; p=0.002) were observed in the post-market group than in the pre-market group.Bev+ patients had significantly better PFS and OS than Bev− patients in univariate (p<0.001 and p<0.001, respectively) and multivariate analyses (PFS: HR=0.36; p<0.001 and OS:HR=0.21; p=0.001, respectively).
Conclusion:Incorporating Bev into frontline chemotherapy may improve outcomes in patients with advanced OCCC.
