Factors Associated With Achieving Complete Skin Clearance Compared to Almost Complete Skin Clearance in Patients With Moderate to Severe Psoriasis Treated With Biologics:A Retrospective Chart Review
- Author:
Eun Ji HONG
1
;
Hee Jung YOON
;
Min Jung KWON
;
Jae Yun KIM
;
Jung Eun KIM
;
Young Lip PARK
;
SangHoon LEE
;
Youin BAE
;
Sul Hee LEE
Author Information
- Publication Type:Original Article
- From:Annals of Dermatology 2024;36(2):91-98
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:Biologics have demonstrated high efficacy in achieving ‘almost complete’ skin clearance in patients with moderate to severe psoriasis. Nonetheless, achieving ‘complete’ skin clearance remains a treatment goal for some highly biologics-resistant patients, as residual lesions impact their quality of life.
Objective:The risk factors for failure to achieve a Psoriasis Area and Severity Index (PASI) 100 response in patients with good response to biologics remain unknown.
Methods:This retrospective study evaluated the risk factors by comparing patients who achieved complete skin clearance (PASI100) with those who achieved almost complete skin clearance (PASI90). A database of 131 psoriasis patients treated with biologics, who achieved a PASI90 or PASI100 response, was reviewed from a tertiary referral hospital in South Korea. The patients were classified into PASI90 and PASI100 groups according to their PASI response.
Results:The PASI100 group had a lower prevalence of smoking history (adjusted odds ratio [OR], 0.34; 95% confidence interval [CI], 0.14–0.85; p=0.021) and psoriasis on the anterior lower legs at baseline (adjusted OR, 0.18; 95% CI, 0.03–0.99; p=0.049) than patients in the PASI90 group.
Conclusion:This study suggested that smoking history and psoriatic skin lesions on the anterior lower legs are considered as the risk factors for the failure to achieve a PASI100 response in psoriasis patients treated with biologics.
