Two-sample Mendelian randomization study for schizophrenia and breast cancer
10.23838/pfm.2019.00093
- Author:
Soyeon KIM
;
Kiwon KIM
;
Woojae MYUNG
;
Hyewon LEE
;
Ho KIM
;
Doh Kwan KIM
;
Hong-Hee WON
- Publication Type:Original Article
- From:
Precision and Future Medicine
2020;4(1):21-30
- CountryRepublic of Korea
-
Abstract:
Purpose:The purpose of this study was to investigate whether the risk of schizophrenia is causally associated with the risk of breast cancer.
Methods:Bidirectional two-sample Mendelian randomization (TSMR) was performed using genome-wide association study summary data from a total of 311,266 individuals. The causal relationship was estimated using an inverse-variance weighted method (IVW). For sensitivity analysis, weighted median, Mendelian randomization (MR)-Egger regression, and Mendelian randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO) were used.
Results:The study showed evidence of a causal association between schizophrenia and the risk of breast cancer. In the IVW analysis, the odds ratio for breast cancer per log odds increase in schizophrenia risk was 1.069 with a 95% confidence interval of 1.028 to 1.112 (P< 0.001). This liability was consistently observed using multiple sensitivity analyses (P< 0.05). By contrast, the TSMR analysis of an inverted direction revealed no significant impact of breast cancer on the risk of schizophrenia.
Conclusion:Our results suggested that schizophrenia and breast cancer may have shared biological backgrounds. Genetic factors associated with schizophrenia might be causally associated with the risk of breast cancer.
