Epidemics of Norovirus GII.4 Variant in Outbreak Cases in Korea, 2004–2012
10.1016/j.phrp.2015.10.002
- Author:
Sunyoung JUNG
1
;
Hyun Ju JEONG
;
Bo-Mi HWANG
;
Cheon-Kwon YOO
;
Gyung Tae CHUNG
;
Hyesook JEONG
;
Yeon-Ho KANG
;
Deog-Yong LEE
Author Information
1. Division of Enteric Diseases, Center for Infectious Diseases, Korea National Institute of Health, Osong, Korea
- Publication Type:Brief Report
- From:
Osong Public Health and Research Perspectives
2015;6(5):318-321
- CountryRepublic of Korea
- Language:English
-
Abstract:
Norovirus GII.4 is recognized as a worldwide cause of nonbacterial outbreaks. In particular, the GII.4 variant occurs every 2–3 years according to antigenic variation. The aim of our study was to identify GII.4 variants in outbreaks in Korea during 2004–2012. Partial VP1 sequence of norovirus GII.4-related outbreaks during 2004–2012 was analyzed. The partial VP1 sequence was detected with reverse transcription-polymerase chain reaction, seminested polymerase chain reaction, and nucleotide sequence of 312-314 base pairs for phylogenetic comparison. Nine variants emerged in outbreaks, with the Sydney variant showing predominance recently. This predominance may persist for at least 3 years, although new variants may appear in Korea.
