Bilateral femoral fracture in a young female Filipina with autoimmune polyendocrine syndrome type 4 and probable Turner's Syndrome: A case report
- Author:
Michelle P. Del Rosario
1
;
Celeste Ong-Ramos
1
;
Nesti James Panopio
1
Author Information
- Publication Type:Case Reports
- Keywords: Autoimmune Polyendocrine Syndrome; Secondary Osteoporosis; Iatrogenic Cushing’s Syndrome
- MeSH: Fractures, Spontaneous; Primary Ovarian Insufficiency; Arthritis, Rheumatoid
- From: Philippine Journal of Internal Medicine 2025;63(4):10-17
- CountryPhilippines
- Language:English
-
Abstract:
Introduction:Autoimmune polyendocrine syndrome (APS) type 4 is a clustering of at least 2 or more organ-specific autoimmune diseases in a single patient, which do not fall into other categories of APS, in combination with at least one more endocrine or non-endocrine organs. The multitude of autoimmune comorbidities and their associated treatment may contribute to osteoporosis and fracture.
Case Description:A 35-year-old female with bilateral distal femoral pathologic fracture from an inch fall underwent bilateral, minimally invasive plate osteosynthesis. Pathologic fracture from secondary osteoporosis resulted from rheumatoid arthritis, chronic steroid use from rheumatoid arthritis (prednisone 10 mg for 24 months), premature ovarian failure since 20 years old without hormone replacement therapy, and possible Turner syndrome. She had persistently elevated thyroid-stimulating hormone in spite of high levothyroxine (4.25 μg/kg/day) dose; hence, gastric malabsorption from possible atrophic gastritis was likewise considered. Benefits and risks associated with treatment were reviewed to manage the patient holistically.
Conclusion:APS is a rare complex syndrome which may lead to various complications. Presence of hypogonadism, rheumatoid arthritis, and chronic steroid use further predisposes the development of secondary osteoporosis. Early screening and treatment of osteoporosis would have decreased the risk of development of fracture. - Full text:20260630144003841643-2024-341.pdf
