Clinical experiences in the diagnosis and management of primaryimmunodeficiency disorders in adults
10.4168/aard.2026.14.1.47
- Author:
Joo-Hee KIM
1
;
Haeng-Jun KIM
;
Hae-Sim PARK
Author Information
1. Department of Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea
- Publication Type:CLINICAL INSIGHTS
- From:Allergy, Asthma & Respiratory Disease
2026;14(1):47-51
- CountryRepublic of Korea
- Language:English
-
Abstract:
Primary antibody deficiency (PAD) is the most common form of primary immunodeficiency (PID) in adults, although the overall prevalence remains low. Recent studies have suggested a rising incidence due to changes in environmental factors and increased awareness. PID typically presents with recurrent upper and lower respiratory tract infections but may also be associated with allergic and autoimmune diseases, resulting in various clinical manifestations. This report presents three representative adult cases of PAD— X-linked agammaglobulinemia (XLA), common variable immunodeficiency (CVID), and IgG3 subclass deficiency (IgG3D) with bronchial asthma—offering insights into their diagnosis and long-term management. These cases emphasize the need to suspect XLA in patients with recurrent pneumonia and bronchiectasis, to recognize chronic severe urticaria as a potential clinical clue for CVID, and to evaluate IgG3D in asthma patients with frequent viral infections despite standard care. Through these examples, this clinical insight underscores the importance of early suspicion of PID, comprehensive immunological evaluation and individualized treatment strategies in improving outcomes for adult PID patients.
