Successful desensitization to contrast media in a patient with recurrent hypersensitivity to multiple iodinated contrast agents: A case report
10.4168/aard.2026.14.2.97
- Author:
Jeong Min PARK
;
Sun Young PAIK
;
Jiung JEONG
;
Young-Chan KIM
;
Heung-Woo PARK
;
Sang-Heon CHO
;
Hye-Ryun KANG
;
Ji-Hyang LEE
- Publication Type:CASE REPORT
- From:Allergy, Asthma & Respiratory Disease
2026;14(2):97-100
- CountryRepublic of Korea
- Language:English
-
Abstract:
Hypersensitivity reactions (HSRs) to iodinated contrast media (ICM) can range from mild cutaneous symptoms to life-threatening anaphylaxis. In patients with a history of ICM hypersensitivity, avoidance of the culprit agent is generally recommended. This case report describes a successful desensitization in a 56-year-old man with recurrent HSRs to multiple agents including ioversol, iohexol, iobitridol, and iopamidol. Intradermal testing was performed to identify potentially safe alternatives; however, all tested agents, including iohexol, ioversol, iobitridol, iopamidol, iodixanol, iomeprol, and iopromide, yielded positive results. Given the clinical necessity of transcatheter arterial chemoembolization, a 13-step rapid desensitization protocol with iodixanol was implemented. The procedure was completed without any breakthrough reactions. This case highlights desensitization as a feasible and effective strategy for patients with hypersensitivity to multiple ICM agents.
