Progress and prospect of modern research methods for safety analysis of animal traditional Chinese medicine
10.19778/j.chp.2026.01.004
- VernacularTitle:动物类中药安全性分析现代研究方法进展与展望
- Author:
YANG Yichun
;
ZHU Zeren
;
HAN Xu
;
ZHANG Yu
;
SU Qi
- Publication Type:Journal Article
- Keywords:
animal traditional Chinese medicine;
safety analysis;
exogenous harmful residues;
endogenous toxic components
- From:
Drug Standards of China
2026;27(1):0021-0027
- CountryChina
- Language:Chinese
-
Abstract:
Exogenous harmful residues and endogenous toxic components are the main contents of safety analysis for animal traditional Chinese medicine. This review summarizes the inspection methods for exogenous harmful residues, as well as the research methods for the toxic effects and mechanisms of endogenous toxic components. The strategies for enhancing efficacy and reducing toxicity of toxic animal drugs and quality control, and prospects the development trend of safety analysis for animal drugs were also discussed. In the detection of exogenous harmful residues in animal drugs, traditional methods such as atomic absorption spectrometry and inductively coupled plasma mass spectrometry are widely used, and new methods such as high-resolution mass spectrometry and biochemical analysis are continuously developing. In the study of endogenous toxic components, the toxic components and mechanisms of some animal drugs including cantharidin and toad venom have been revealed through chemical composition analysis, toxicity tests and multiomics technologies, and some strategies for enhancing efficacy and reducing toxicity have been proposed based on this. In the future, it is necessary to strengthen multidisciplinary integration to innovate detection technologies, clarify toxic mechanisms to achieve efficacy enhancement and toxicity reduction, and improve the biosafety research system, so as to enhance the quality and safety of traditional Chinese medicine animal drugs and promote the internationalization process of traditional Chinese medicine.
- Full text:202606291103123152720260204.pdf
