Research strategy for key quality attributes of traditional Chinese medicine based on systems biology and chemical biology
10.19778/j.chp.2026.01.003
- VernacularTitle:系统生物学与化学生物学驱动中药关键质量属性研究
- Author:
HOU Yuanyuan
;
ZHANG Man
;
JIANG Min
;
ZHANG Tiejun
;
BAI Gang
- Publication Type:Journal Article
- Keywords:
quality control of traditional Chinese medicine;
quality markers;
potency;
systems biology;
chemical biology
- From:
Drug Standards of China
2026;27(1):0015-0020
- CountryChina
- Language:Chinese
-
Abstract:
Currently, the quality control of traditional Chinese medicine (TCM) encounters substantial technical challenges, necessitating the urgent development of innovative evaluation methods for key quality attributes. This study proposes the construction of a quality assurance system centered on key quality attributes, with systems biology and chemical biology serving as its core components: utilizing multi-omics technologies to systematically analyze the core functional modules of TCM, integrating pharmacological approaches to precisely identify key bioactive components; applying chemical biology to elucidate the interaction mechanisms between components and their targets, while screening for quality markers associated with specific functions and clinical indications; establishing an integrated quality control system based on quality markers and biological potency to ensure comprehensive quality management from raw herb materials through to finished products. Additionally, it emphasizes the formulation of compatibility rules grounded in TCM theory, integrates clinical practice and multi-dimensional value assessments, and establishes a novel quality evaluation model with distinct TCM characteristics.This offers a comprehensive and systematic approach to ensuring the safety and efficacy of TCM while facilitating the high-quality development of the TCM industry.
- Full text:202606291100453463620260203.pdf
