Curcumin Improved Superoxide Dismutase Concentration but Failed to Decrease Malondialdehyde Concentration After a Series of Estradiol Benzoate Injection in Mice
10.47836/mjmhs.v22.i1.1472
- Author:
Mukhoirotin
1
;
Bambang Purwanto
2
;
Ernawati
3
;
Abdul Khairul Rizki Purba
4
;
Hamimatus Zainiyah
5
Author Information
1. Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Indonesia; Department of Nursing, Faculty of Health Science, Universitas Pesantren Tinggi Darul Ulum (Unipdu), Indonesia.
2. Department of Physiology and Medical Biochemistry, Faculty of Medicine, Universitas Airlangga, Indonesia
3. Department of Obstetric Gynecology, Faculty of Medicine, Universitas Airlangga, Indonesia
4. Department of Pharmacology, Faculty of Medicine, Faculty of Medicine, Universitas Airlangga, Indonesia; Department of Health Science, University Medical Center Groningen, University of Groningen, The Netherlands
5. Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Indonesia; Institute of Health Science, Ngudia Husada, Bangkalan, Madura, Indonesia
- Publication Type:Journal Article
- Keywords:
Curcumin;
Dysmenorrhea;
Estradiol;
Antioxidant;
Oxidative stress
- From:
Malaysian Journal of Medicine and Health Sciences
2026;22(No. 1):1-8
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Estradiol benzoate is widely used to mimic dysmenorrhea in mice, inducing oxidative stress and inflammation during menstruation. Since curcumin is a potent natural antioxidant, it presumably decreases dysmenorrhea and oxidative stress during menstruation. This study aims to investigate the effect of curcumin on superoxide
dismutase (SOD) and malondialdehyde (MDA) concentration in estradiol benzoate-induced dysmenorrhea in mice.
Methods: Forty mice were randomly grouped into five groups. The first three groups were treated with curcumin
twice a day with 100 mg/kg (Dys+Cur100), 200 mg/kg (Dys+Cur200), and 400 mg/kg (Dys+Cur400) in corn oil. The
next two groups were treated with either 100 mg/kg ibuprofen (Dys+Ibu) or corn oil as placebo (Dys). Oxytocin was
used to induce a writhing response to pain in mice. On day 11, blood serum was taken for examination of SOD and
MDA concentration in mice. Results: Significant differences were observed between the SOD concentration in the
Dys+Cur100 vs. Dys group (p < 0.05). The MDA concentration did not differ between groups (p > 0.05). Although
the antioxidant effect of curcumin failed to lower the MDA concentration, it succeeded in elevating the SOD concentration in mice treated with 100 mg curcumin. Conclusion: The antioxidant activity of curcumin improved SOD
levels but not MDA levels in dysmenorrhea-induced mice, highlighting the indirect effect of curcumin on dysmenorrhea treatment.
- Full text:202606261125194557414+1278+JAN+C.pdf
