Research progress on pathogenesis, clinical detection and precision treatment of fibroblast growth factor 23-related hypophosphatemia
10.13200/j.cnki.cjb.004725
- VernacularTitle:成纤维细胞生长因子23相关低磷血症致病机制、临床检测及精准诊疗的研究进展
- Author:
Liqin ZHU
- Publication Type:Journal Article
- Keywords:
Fibroblast growth factor 23(FGF23);
X-linked hypophosphatemia(XLH);
Tumor-induced osteomalacia(TIO);
Biomarker;
Targeted therapy
- From:
Chinese Journal of Biologicals
2026;39(06):747-755
- CountryChina
- Language:Chinese
-
Abstract:
Fibroblast growth factor 23(FGF23) is the main hormone that controls phosphorus metabolism and is involved in the occurrence of both inherited and acquired hypophosphatemia.This review systematically expounds the molecular characteristics of FGF23,its regulation at the translation and transcription,and the core pathophysiological mechanisms by which FGF23 mediates hypophosphatemia,including the inhibition of renal sodium-phosphate cotransporter expression and active vitamin D metabolism,ectopic secretion,genetic lineage mutations,and iatrogenic factors leading to decreased serum phosphorus.It also elaborates the clinical diagnostic value of FGF23 in X-linked hypophosphatemia(XLH),tumor-induced osteomalacia(TIO),and chronic condition,as well as its important role as a prognostic biomarker to predict the chronic kidney disease and cardiovascular diseases.The significant role of serum FGF23 detection in clinical diagnosis was described in detail,and the problem of inconsistent standardization of different detection kits was discussed.In clinical treatment,using traditional phosphate and active vitamin D as the foundation,the emergence of targeted FGF23 monoclonal antibodies,such as burosumab,means the entry of hypophosphatemia treatment into the era of precise treatment.This review aims to provide a scientific basis for a deeper understanding of FGF23 in the comprehensive treatment and management of diseases,turning FGF23 from the scientific and clinical basic research into a refined,multidisciplinary integrated therapeutic approach.
