Research progress on the vaccines for Fusobacterium nucleatum
10.13200/j.cnki.cjb.004707
- VernacularTitle:具核梭杆菌疫苗的研究进展
- Author:
Qi WEN
- Publication Type:Journal Article
- Keywords:
Fusobacterium nucleatum(Fn);
Colorectal cancer;
Reverse vaccinology;
Vaccine
- From:
Chinese Journal of Biologicals
2026;39(05):613-620
- CountryChina
- Language:Chinese
-
Abstract:
Fusobacterium nucleatum(Fn) is a common oral symbiotic bacterium and opportunistic pathogen that has been found to be closely related to many human diseases in recent years, such as inflammatory bowel disease, colorectal cancer,oral cancer, breast cancer, rheumatoid arthritis, and preterm birth. Currently, clinical treatment methods targeting this bacterium have limited effectiveness, and Fn vaccines may become an important direction for breaking through existing treatment bottlenecks. At present, Fn vaccines are still in the laboratory research and development stage, and various vaccine designs have adopted reverse vaccinology strategies, mainly focusing on subunit vaccines. Reverse vaccinology integrates genomic data with bioinformatics techniques to systematically predict and screen pathogenic antigen epitopes. Combined with high-throughput cloning, expression, and immunological evaluation, it allows for the efficient identification of protective antigens, significantly shortening the vaccine development cycle. This article focuses on the potential antigen targets and vaccine design strategies for Fn, providing a theoretical basis for developing vaccines against diseases related to Fn.
