TCM Syndrome Distribution Patterns and Clinical Characteristics in Patients with Chronic Hepatitis B Comorbid with Metabolically Associated Fatty Liver Disease
10.13422/j.cnki.syfjx.20251014
- VernacularTitle:慢性乙型肝炎合并代谢相关性脂肪性肝病的中医证候分布规律及临床特征分析
- Author:
Dingqi LI
1
;
Liang HUANG
2
;
Baixue LI
3
;
Rui ZHAO
4
;
Zhenglong ZHENG
1
;
Yichen PENG
1
;
Yu LIANG
1
;
Caiying HE
3
;
Jingdong CUI
1
;
Zilin XIONG
1
;
Xiyang LIU
3
;
Quansheng FENG
3
Author Information
1. School of Clinical Medicine， Chengdu University of Traditional Chinese Medicine（TCM）， Chengdu 610075，China
2. Public Health Clinical Center of Chengdu， Chengdu 610000，China
3. School of Basic Medical Sciences， Chengdu University of TCM，Chengdu 610075，China
4. School of Medical Technology， Chengdu University of TCM， Chengdu 610075，China
- Publication Type:Journal Article
- Keywords:
chronic hepatitis B;
metabolically associated fatty liver disease;
syndrome distribution;
damp-heat accumulation syndrome;
clinical feature
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(14):259-270
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveThis paper aims to investigate the distribution patterns of traditional Chinese medicine syndromes in patients with chronic hepatitis B （CHB） comorbid with metabolically associated fatty liver disease （MAFLD） and analyze their correlation with clinical characteristics and the progression of liver fibrosis. MethodsA cross-sectional study method was employed， and 506 patients with CHB comorbid with MAFLD who attended the Hepatology Outpatient Department of Public Health Clinical Center of Chengdu from June 2024 to December 2024 were enrolled. General information， traditional Chinese medicine syndromes information， laboratory indicators， and imaging examination results were collected using case report forms （CRF）. Tongue images of patients were acquired using a tongue diagnosis instrument， and tongue feature parameters were extracted using computer image processing technology. Frequency analysis， factor analysis， and cluster analysis， and other methods were used to explore syndrome categories and distribution patterns. Non-parametric tests were used to compare the differences in clinical characteristics among different syndromes. Univariate and multivariate logistic regression analyses were performed to investigate the correlation between traditional Chinese medicine syndromes and the progression of liver fibrosis. ResultsThe main traditional Chinese medicine syndromes in patients with CHB comorbid with MAFLD were mainly dominated by damp-heat accumulation syndrome， liver stagnation and spleen deficiency syndrome， and phlegm-blood stasis syndrome， with damp-heat accumulation syndrome accounting for the highest proportion （41.89%）. Compared with those without damp-heat accumulation syndrome， patients with damp-heat accumulation syndrome had significantly lower tongue proper H value， tongue coating H value， and tongue coating a* value （P<0.05）， significantly higher tongue coating b* value （P<0.05）， significantly increased levels of white blood cell （WBC）， red blood cell （RBC）， hemoglobin （HGB）， and glucose （GLU）， increased CAP values （P<0.05）， a higher proportion of males （P<0.05）， and a younger age （P<0.05）. Univariate and multivariate logistic regression analyses show that age， hepatitis B surface antigen （HBsAg）， diabetes， and damp-heat accumulation syndrome are independent risk factors for liver fibrosis （P<0.05）， and that damp-heat accumulation syndrome is predominantly distributed in liver fibrosis stage F0-F1. ConclusionDamp-heat accumulation syndrome is a typical syndrome in patients with CHB comorbid with MAFLD， which is significantly associated with enhanced inflammatory response， metabolic disorders， and early liver fibrosis， and is a key link in disease progression. Clinical attention and early intervention are needed.
